It will determine your medication sensitivity and reduce the chance of a possible adverse drug reaction. Ppt pharmacogenetics powerpoint presentation free to view. The promise and reality of pharmacogenetics in psychiatry ncbi. Nov 10, 2014 conclusion nonetheless, the potential utility of pharmacogenetics to optimize drug therapy is great. Pharmacogenetics of propofol and depth of anesthesia. Pharmacogenetics is the study of the impact of genetic polymorphisms on drug response. The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. The subject area of pharmacogenetics, also known as pharmacogenomics, has a long history. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. Pharmacogenomics of opioids and perioperative pain. Pharmacogenomics pharmacogenomics refers to the role of various components of the genome on response to a drug. While this may be carried out as a part of the drug discovery process, the film whats so controversial about. Recent progress in the science of clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies.
For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. Principles of pharmacogenetics and pharmacogenomics. Presence of egfr t790m mutation at presentation shorter time to. An individuals response to a certain drug based on variations in their genes encoding for drugmetabolizing enzymes, drug receptors, drug transporters or drug targets. Surajit pharmacogenetics authorstream presentation. This genetic test that analyzes how your genetic makeup affects your unique response to medication. Pharmacogenetics pgx is the study of how genetic variation changes an individuals response to a medication a single nucleotide polymorphism snp is the most common type of genetic variation if a snp affects the function of a gene that codes for a drug metabolizing enzyme or a drug transporter or a drug. Microsoft powerpoint 2010 free trial gives you more ways to create and share dynamic presentations with your audience than ever before.
Role of pharmacogenomics in ppt authorstream presentation. Pharmacogenetics and pharmacogenomics knowledge base pharmgkb publicly accessible knowledge base. Introduction to pharmacokinetics and pharmacodynamics. The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous eeg and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination. Jul 02, 2016 pharmacogenetics and pharmacogenomics is an upcoming branch in therapeutics. Propofol, 2,6diisopropylphenol is a shortacting anesthetic drug used for induction and maintenance of anesthesia. Find powerpoint presentations and slides using the power of, find free presentations research about pharmacogenetics ppt. Case studies in pharmacogenetics mike pacanowski, pharmd, mph office of clinical pharmacology center for drug evaluation and research pediatric advisory committee. The selection of drugs based upon a oneoff acquisition of genetic information has the potential to facilitate the selection of the most efficacious drugs at the optimal dose, and avoid many severe adverse effects. Pharmacogenetics has clear potential to influence the practice of medicine. When taken correctly and with no interruption from gene mutations, drugs cause beneficial effect reactions.
This application contains upgraded programs such as word, excel, powerpoint, and one note. National institute of health pharmacogenetics research networks pharmgkb. A free powerpoint ppt presentation displayed as a flash slide show on id. Candidate genes associated with response and side effectstoxicity are known. Microsoft powerpoint 2010 publishers description if you would like to try the application, you must apply for a trial product key at. Pharmacogenomics explores the ways such variations can be used to predict responses to investigational products and plays an increasingly important role in drug discovery. Taar6 variation effect on clinic presentation and outcome in a. The pharmacogenetics and the pharmacogenomics knowledge base. Apr 05, 2012 adoption of pharmacogenetics in clinical practice promises more effective decisionmaking with regard to diagnostic testing, drug selection and dosing. Some people respond differently to a drug than other people do. I pharmacogenomics and pharmacogenetics andrew a somogyi and janet k coller encyclopedia of life support systems eolss role and importance that pharmacogenetics can play in the pharmacokinetics metabolism and transport and inherent pharmacodynamic properties of drugs.
Warfarin pharmacogenetics in guidelines and understanding the place of warfarin pharmacogenetics in therapy after coag and eupact. As the drug experts, pharmacists should be familiar with all factors that affect pharmacotherapy pharmacy benefit managers are starting to incorporate pharmacogenetics into the drug approval and reimbursement process. This system is used for most genes with welldefined. Pharmacogenetics is an emergent field aimed at tailoring pharmacological therapy. Pharmacogenetics is not a new subject area but its relevance to drug.
The research component centers on a randomized blinded controlled trial investigating the association between gene variants in intermediary metabolic pathways known to be altered by nitrous oxide and postoperative myocardial ischemia. Pharmacogenetics pgx is the study of how genetic variation changes an individuals response to a medication a single nucleotide polymorphism snp is the most common type of genetic variation if a snp affects the function of a gene that codes for a drug metabolizing enzyme or a. I pharmacogenomics and pharmacogenetics andrew a somogyi and janet k coller encyclopedia of life support systems eolss variant is in this case a basepair deletion at position 2549 and the letter b indicates an additional snp at position 1749. This k23 proposal is for a career development program in perioperative pharmacogenetics. Dpd is responsible for catabolism of 5fluorouracil.
I want to start with a quote read it this is from hippocrates, one of the great men of ancient greece, the father of western medicine weve known for a long time but just now, with the development. There are two major sets of guidelines regarding warfarin pharmacogenetics, although both were published prior to publication of the most recent randomized controlled trials. It has shown to have promising results in personalized medicine it is my attempt to compile the basic concepts from various books, articles, and online journals. The term pharmacogenetics panel was coined by motulsky. Membrane transporters are heavily involved in drug clearance and alters drug disposition by actively transporting substrate drugs between organs and tissues. Pharmacogenetics of propofol and depth of anesthesia full. Study of interindividual variation in dna sequence related to drug absorption. Clinical dnabased testing began in 1978 with the diagnosis of sickle cell disease by interrogating the causative p. Ppt pharmacogenomics powerpoint presentation free to. Pharmacogenetics and individual variation of drug response. This is a pdf file of an unedited manuscript that has been. In this paper, we discuss the possibility that therapeutic drug monitoring tdm in the future will involve not the mere measurement and interpretation of drug concentrations but will include both.
The future of pharmacogenetics in the treatment of hypertension. Pharmacogenetics in patient care 60% of drugs causing adr are metabolized by polymorphic enzymes detect polymorphism of genes coding for drug metabolism assists in dosage selection or modification ex. For example, knowledge on genetic determinants of disease pathogenesis and drug action, especially those of complex disease and drug response, is not always available. New algorithms based on haplotype analysis are being developed to estimate. Integration of pharmacogenetics into clinical practice mary v. Pharmacogenetics, pharmacogenomics, and individualized medicine. Jun 01, 2011 challenges to future pharmacogenomics and its translation into individualized medicine, drug development, and regulation are discussed. Research in this area has led to fundamental discoveries, which have helped our understanding of the reasons why individuals differ in the way they handle drugs, and ultimately in the way they respond to drugs, either in terms of efficacy or toxicity. Pdf practical recommendations for pharmacogenomicsbased. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or.
Advantage they need only be conducted once during an individuals lifetime. Integrating pharmacogenetic effects on pharmacokinetics in drug development. Microsoft office 2010 torrent is the updated and fresh version of microsoft office productivity suite supporting microsoft windows. Download microsoft powerpoint 2010 microsoft office. Hypertension is an important risk factor for heart disease and affects more than one billion individuals worldwide and one third of the us adult population 2, 3.
Heart disease remains the leading cause of death in the united states us, accounting for approximately 610,000 deaths annually. It improves individualized therapy and gives crucial approach. Pharmacogenetics oxford monographs on medical genetics. Thus, computational murine pharmacogenetic analysis can facilitate the identification and characterization of drug metabolism pathways that. Baixar office 2010 3264 bits completo ptbr via torrent. Jude childrens research hospital and paar4kids, nih pharmacogenomics research network. Because we are able to study pharmacogenetics, we are better able to determine or predict. The term pharmacogenetics often is used interchangeably with the term pharmacogenomics.
Various pharmacogenomic tests are currently available to aid in actual clinical practice. The last couple of decades have been revolutionized by the implementation of the us human genome project. Ppt pharmacogenetics powerpoint presentation free to. Pharmacogenetics, volume 83, the newest volume in the advances in pharmacology series, presents a variety of chapters and the best authors in the field, with this release highlighting regulatory perspectives, the implementation of pharmacogenetics in everyday clinical setting, imaging in pharmacogenetics, pharmacoepidemiology in pharmacogenetics, epigenetics and micro rna in pharmacogenetics. Powerpoint 2010 will be retired in 2020 get the most uptodate version of powerpoint and easily create polished presentations. Pharmacogenetics testing your unique response to medication. View and download powerpoint presentations on pharmacogenetics ppt. Clinical pharmacogenetics, the use of genetic data to guide drug therapy decisions, is beginning to be used for medications commonly prescribed by family physicians.
The activity of drugmetabolizing enzymes often varies widely among healthy people, making metabolism highly variable. As noted in the film pharmacogenetics involves patients consenting to a genetic test 1. Pharmacogenomics is the study of the role of the genome in drug response. Baixar office 2010 3264 bits completo ptbr via torrent downloads gratis sem virus com link direto. Pharmacogenomics is the property of its rightful owner. Although the field of pharmacogenetics was established in the 1950s, clinical testing for constitutional pharmacogenetic variants implicated in interindividual drug response variability has only recently become available to help clinicians guide pharmacotherapy, in. Pharmacogenetic tests are used to help predict how an individual will respond to a particular medication. Implications of pharmacogenomics for anesthesia providers. Oct 04, 2012 pharmacogenetics is often a study of the variations in a targeted gene, or group of functionally related genes. Nov 16, 2016 pharmacogenetics and pharmacogenomics is an emerging science that has a great application in drug development and therapeutics. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Pharmacogenetics and pharmacogenomics is an emerging science that has a great application in drug development and therapeutics.
Dec 10, 2009 propofol, 2,6diisopropylphenol is a shortacting anesthetic drug used for induction and maintenance of anesthesia. Encepp plenary meeting introduction to pharmacogenomics marisa papaluca. Pharmacogenetics involves variations in drug response due to genetic makeup. In 2010, valderbilt university medical center launched pharmacogenomic resource. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeineprescribed mother. Mechanisms of action, adverse effects and indications of psychotropic medications. Pharmacogenetics of remifentanil in patients with hypertension undergoing cesarean delivery under general anesthesia the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
List item guideline on the use of pharmacogenetic methodologies in. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or. Powerpoint presentations on pharmacogenomics and personalized. Pharmacogenomics, on the other hand is a much broader investigation of genetic variations at the level of the genome pharmacogenomics includes pharmacogenetics 6. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism. However, pharmacogenetics generally refers to monogenetic variants that affect drug response, whereas pharmacogenomics refers to the entire spectrum of genes that interact to determine drug efficacy and safety. Pharmacogenetics and pharmacogenomics pharmacogenetics and pharmacogenomics kevin zbuk.
Pharmacogenetics presentation slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Pharmacogenetics is the study of inherited variation in drug response. Pharmacogenomics analyzes how the genetic makeup of an individual affects hisher response to drugs. An introduction to pharmacogenomics ashim malhotra p glycoprotein, 111 clinical implications of pharmacogenomics, 111 adverse drug reactions warfarin pharmacogenetic testing prior to prescribing summary, 1 a dvances in health care have led to a significant improvement in patient survival in the past three decades. Many drugs are intrinsically unsafe and could be made safer. More codeine fatalities after tonsillectomy in north american children. Pharmacogenetics pgt is a subset of pharmacogenomics pgx and is defined as. Integration of pharmacogenetics into clinical practice. This was a year effort coordinated by the us department. Pharmacogenomics definition of pharmacogenomics by.
Pharmacogenetics merck manuals professional edition. Each haplotype can be identified by just five tagging snps tsnps, and the. Molecular mechanism of genetic polymorphism genetic variation occuring with a frequency of 1% or more in the population 1. The goal of pharmacogenetics is to develop novel ways of maximizing drug efficacy and minimizing toxicity for individual patients. If you continue browsing the site, you agree to the use of cookies on this website. With continued incorporation of pharmacogenetics into clinical trials, the important genes and polymorphisms will be identified. Pharmacogenetics and pharmacogenomics is an upcoming branch in therapeutics. In this section, we describe some future applications of pharmacogenetics and provide contemporary examples that reflect how these topics may be applied to a clinical setting. Pharmacogenomics steps toward personalized medicine pdf. Powerpoint presentations on pharmacogenomics and personalized medicine. If there is a search for a tool which aids a completely nonit person to prepare a presentation in the quickest and easiest manner, ms office powerpoint 2010 is a good option. Among the most commonly studied are genetic sequence variants, structural changes in chromosomes eg, translocations, epigenetic variants eg, changes in gene methylation, and variation in the expression profile of genes. Pharmacogenetics emerged as a field aimed at identifying heritable factors that are predictive of individual variations in drug efficacy and toxicity from the dedicated work of a small group of investigators who in the 1950s began to enrich the discipline of pharmacology by integrating it.